The overall research activities of the two groups at the Division of Molecular Immunology concentrate on molecular aspects of the humoral immune response in health and disease. Particularly, we are interested in signaling pathways and factors involved in B cell maturation and selection of normal B lymphocytes and in antigen-induced terminal differentiation of plasma cells. In addition, we study how non-functional (nonsense) Ig-mRNA is degraded (nonsense codon-mediated mRNA decay = NMD) and whether aberrant polypeptides encoded by non-functional mRNA contribute to the pathogenesis of Alzheimer’s disease.